Reasons for inclusion

• You are female and over 16 years of age.

Reasons for exclusion

• You have a known hypersensitivity to norethisterone or to any of the excipients
• You are pregnant or suspect that you are.
• You have a presence or history of severe hepatic disease as long as liver function values have not returned to normal
• You have undiagnosed genital bleeding
• You have any previous idiopathic or current thromboembolism (deep vein thrombosis, pulmonary embolism).
• You have an active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction).
• You have porphyria
• You have epilepsy.
• You have asthma.
• You have cardiac dysfunction.
• You have renal dysfunction
• You have diabetes mellitus with vascular involvement
• You have rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
• You are taking other sex hormones, including contraception
• You are taking inducers of drug-metabolising enzymes, especially cytochrome P450 enzymes, including: anticonvulsants (e.g. phenobarbital, phenytoin, carbamazepine) and anti-infectives (e.g. rifampicin, rifabutin, nevirapine, efavirenz, tetracyclines, ampicillin, oxacillin and co-trimoxazole)
• You are taking ritonavir and nelfinavir
• You are taking herbal preparations containing St John s Wort (Hypericum Perforatum)
• You are taking Aminoglutethimide
• You are taking Ciclosporin
• You are lactating
• You have a presence or a history of prodromi of a thrombosis (e.g. transient ischaemic attack, angina pectoris)
• You have a high risk of venous or arterial thrombosis
• You have previous or existing liver tumours (benign or malignant)
• You have known, past or suspected sex hormone-dependent malignancies, including breast or genital tract carcinoma
• You have a history of migraines with focal neurological symptoms
• History during pregnancy of idiopathic jaundice, severe pruritus, or pemphigoid gestationis
• You have untreated endometrial hyperplasia
• You have an active trophoblastic disease (until return to normal of urine- and plasma gonadotrophin concentration) – seek specialist advice. Patients should not use norethisterone after a recent evacuation of a hydatiform mole
• You are taking nbsp;Anticoagulants
• You are taking Griseofulvin
• You are taking Amprenavir, taking Selegiline, taking Tizanidine